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GENE - TERM ANNOTATION REPORT

RGD ID: 732461
Species: Homo sapiens
RGD Object: Gene
Symbol: APBA1
Name: amyloid beta precursor protein binding family A member 1
Acc ID: GO:0007268
Term: chemical synaptic transmission
Definition: The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Definition Source(s): GOC:jl, MeSH:D009435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
APBA1involved_inIEAUniProtKB:B2RUJ5 or ensembl:ENSMUSP00000025830150520179Ensembl GO_REF:0000107
APBA1involved_inIBAMGI:1261791 or MGI:1860297 or MGI:1888527 or PANTHER:PTN000960968 or WB:WBGene00002999150520179GO_Central GO_REF:0000033
APBA1acts_upstream_of_or_withinISOMGI:1261791 or MGI:18885279068941MGI PMID:17167098

PMID:17167098
APBA1acts_upstream_of_or_withinISOMGI:24507299068941MGI PMID:17167098

PMID:17167098
APBA1involved_inTAS 150520179PINC PMID:9753324

PMID:9753324
APBA1involved_inIEAPANTHER:PTHR12345:SF14150520179TreeGrafter GO_REF:0000118
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