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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732449
Species: Mus musculus
RGD Object: Gene
Symbol: Nphs2
Name: nephrosis 2, podocin
Acc ID: CHEBI:27470
Term: folic acid
Definition: An N-acyl-amino acid that is a form of the water-soluble vitamin B9. Its biologically active forms (tetrahydrofolate and others) are essential for nucleotide biosynthesis and homocysteine remethylation.
Chemical ID: MESH:D005492
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nphs2decreases expressionEXP 6480464CTDFolic Acid deficiency results in decreased expression of NPHS2 proteinPMID:21647593 PMID:21893018
Nphs2multiple interactionsEXP 6480464CTD[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA; CYBB mutant form inhibits the reaction [Folic Acid deficiency results in decreased expression of NPHS2 protein]; CYBB protein mutant form inhibits the reaction [[Folic Acid deficiency results in increased abundance of Homocysteine] which results in decreased expression of NPHS2 mRNA]PMID:20116427 PMID:21647593
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