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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732441
Species: Homo sapiens
RGD Object: Gene
Symbol: TXN
Name: thioredoxin
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TXNdecreases response to substanceEXP 6480464CTDTXN protein results in decreased susceptibility to TetrachlorodibenzodioxinPMID:11462148
TXNmultiple interactionsEXP 6480464CTDTXN protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR mRNA]PMID:11462148
TXNaffects expressionISOTxn1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of TXN1 mRNAPMID:34747641
TXNaffects expressionISOTxn1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of TXN1 mRNAPMID:21570461
TXNincreases expressionISOTxn1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of TXN1 mRNAPMID:16214954 PMID:17942748
TXNmultiple interactionsISOTxn1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of TXN1 mRNAPMID:17942748
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