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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732407
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT2
Name: AKT serine/threonine kinase 2
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT2multiple interactionsEXP 6480464CTD[Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] affects the expression of AKT2 mRNA; [Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in decreased expression of AKT2 mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which affects the expression of AKT2 mRNA; [Air Pollutants results in increased abundance of Ozone] which affects the expression of AKT2 mRNA; [Oxygen co-treated with Ozone co-treated with Cannabidiol] results in decreased expression of AKT2 mRNA; [Oxygen co-treated with Ozone] results in decreased expression of AKT2 mRNA; [Volatile Organic Compounds co-treated with Ozone] affects the expression of AKT2 mRNAPMID:32699268 PMID:32845096 PMID:32992648 PMID:35430440
AKT2decreases expressionISOAkt2 (Rattus norvegicus)6480464CTDOzone results in decreased expression of AKT2 mRNAPMID:33217375 PMID:33524448
AKT2multiple interactionsISOAkt2 (Mus musculus)6480464CTDOzone promotes the reaction [Soot results in increased phosphorylation of AKT2 protein]PMID:27570198
AKT2multiple interactionsISOAkt2 (Rattus norvegicus)6480464CTD[Coconut Oil co-treated with Ozone] results in decreased expression of AKT2 mRNA; [Fish Oils co-treated with Ozone] results in decreased expression of AKT2 mRNA; [Ozone co-treated with Chlorine] results in decreased expression of AKT2 mRNAPMID:18636392 PMID:33217375
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