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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732401
Species: Homo sapiens
RGD Object: Gene
Symbol: MYH9
Name: myosin heavy chain 9
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MYH9affects expressionISOMyh9 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of MYH9 mRNAPMID:21570461
MYH9decreases expressionISOMyh9 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of MYH9 mRNA; Tetrachlorodibenzodioxin results in decreased expression of MYH9 proteinPMID:16054898 PMID:16548065 PMID:33387578
MYH9increases expressionISOMyh9 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of MYH9 mRNAPMID:19770486
MYH9multiple interactionsISOMyh9 (Mus musculus)6480464CTD[blebbistatin results in decreased activity of MYH9 protein] promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]PMID:21216307
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