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GENE - TERM ANNOTATION REPORT

RGD ID: 732365
Species: Homo sapiens
RGD Object: Gene
Symbol: POLA1
Name: DNA polymerase alpha 1, catalytic subunit
Acc ID: GO:0006269
Term: DNA replication, synthesis of primer
Definition: The synthesis of a short nucleotide polymer using one strand of unwound DNA as a template. The product is usually a RNA molecule between 4-15 nucleotides long that provides a free 3'-OH that can be extended by DNA-directed DNA polymerases. In certain conditions, for example in response to DNA damage, some primases synthesize a DNA primer.
Definition Source(s): PMID:11395402, PMID:38203225, PMID:38492718
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
POLA1involved_inIEAUniProtKB:P33609 or ensembl:ENSMUSP00000006856150520179Ensembl GO_REF:0000107
POLA1involved_inIDA 150520179UniProt PMID:2175912 PMID:27019227 PMID:8026492

PMID:2175912 PMID:27019227 PMID:8026492
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