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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732300
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC1A2
Name: solute carrier family 1 member 2
Acc ID: CHEBI:8863
Term: Riluzole
Definition: A benzothiazole that has formula C8H5F3N2OS.
Chemical ID: MESH:D019782
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC1A2increases expressionISOSlc1a2 (Rattus norvegicus)6480464CTDRiluzole results in increased expression of SLC1A2 mRNA; Riluzole results in increased expression of SLC1A2 proteinPMID:22966415
SLC1A2multiple interactionsISOSlc1a2 (Rattus norvegicus)6480464CTDRiluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 mRNA]; Riluzole inhibits the reaction [manganese chloride results in decreased expression of SLC1A2 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of and results in decreased activity of SLC1A2 protein]; Riluzole inhibits the reaction [methylmercuric chloride results in decreased expression of SLC1A2 mRNA]PMID:19615351 PMID:22966415
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