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GENE - TERM ANNOTATION REPORT

RGD ID: 732291
Species: Mus musculus
RGD Object: Gene
Symbol: Fgfr1
Name: fibroblast growth factor receptor 1
Acc ID: DOID:3070
Term: malignant glioma
Definition: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Definition Source(s): MESH:D005910, http://en.wikipedia.org/wiki/Malignant_glioma
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:7322908554872ClinVarClinVar Annotator: match by term: Brainstem glioma

PMID:10766980, PMID:23819449, PMID:26619011, PMID:26822237, PMID:26942290, PMID:27626068
 ISORGD:7322908554872ClinVarClinVar Annotator: match by term: Brainstem glioma

PMID:26619011
 ISORGD:73229011554173CTDCTD Direct Evidence: marker/mechanism

PMID:23583981
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.