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GENE - TERM ANNOTATION REPORT

RGD ID: 732291
Species: Mus musculus
RGD Object: Gene
Symbol: Fgfr1
Name: fibroblast growth factor receptor 1
Acc ID: DOID:1924
Term: hypogonadism
Definition: Condition resulting from deficient gonadal functions, such as GAMETOGENESIS and the production of GONADAL STEROID HORMONES. It is characterized by delay in GROWTH, germ cell maturation, and development of secondary sex characteristics. Hypogonadism can be due to a deficiency of GONADOTROPINS (hypogonadotropic hypogonadism) or due to primary gonadal failure (hypergonadotropic hypogonadism).
Definition Source(s): MESH:D007006, http://en.wikipedia.org/wiki/Hypogonadism
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:7322908554872ClinVarClinVar Annotator: match by term: Hypogonadotropic hypogonadism

PMID:12627230, PMID:17200176, PMID:25636053
 ISORGD:7322908554872ClinVarClinVar Annotator: match by term: Isolated hypogonadotropic hypogonadism

PMID:11173846, PMID:14513299, PMID:15793702, PMID:25741868
 ISORGD:7322908554872ClinVarClinVar Annotator: match by term: Isolated hypogonadotropic hypogonadism

PMID:16882753, PMID:25636053, PMID:25741868
 ISORGD:7322908554872ClinVarClinVar Annotator: match by term: Isolated hypogonadotropic hypogonadism

PMID:25636053
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.