GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Mapk8 | multiple interactions | EXP | | 6480464 | CTD | [[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of MAPK8 protein; [Disulfiram binds to Copper] which results in increased phosphorylation of MAPK8 protein; pyrazolanthrone inhibits the reaction [[[cupric chloride results in increased abundance of Copper] co-treated with [zinc chloride results in increased abundance of Zinc]] results in increased phosphorylation of MAPK8 protein] | PMID:24690739 PMID:30768131 | Mapk8 | multiple interactions | ISO | Mapk8 (Rattus norvegicus) | 6480464 | CTD | [[Copper binds to neocuproine] which results in increased activity of MAPK8 protein] which results in increased phosphorylation of JUN protein; [Copper binds to neocuproine] which results in increased activity of MAPK8 protein; [Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK8 protein; [pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of MAPK8 protein; Acetylcysteine inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK8 protein]; bathocuproine sulfonate inhibits the reaction [[Copper binds to neocuproine] which results in increased activity of MAPK8 protein]; bathocuproine sulfonate inhibits the reaction [[pyrrolidine dithiocarbamic acid co-treated with Copper] results in increased activity of MAPK8 protein]; pyrazolanthrone inhibits the reaction [[Copper co-treated with pyrrolidine dithiocarbamic acid] results in increased phosphorylation of MAPK8 protein] | PMID:10941151 PMID:18056745 PMID:22085843 | Mapk8 | multiple interactions | ISO | MAPK8 (Homo sapiens) | 6480464 | CTD | [Chelating Agents binds to Copper] which results in increased expression of MAPK8 mRNA; [Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein; [Disulfiram binds to Copper] which results in increased phosphorylation of MAPK8 protein; Copper inhibits the reaction [IAPP protein results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of MAPK8 protein] | PMID:16648635 PMID:23793354 PMID:24690739 PMID:30911355 | | ||||||||||||||||||||||
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