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GENE - TERM ANNOTATION REPORT

RGD ID: 732271
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK8
Name: mitogen-activated protein kinase 8
Acc ID: GO:0007254
Term: JNK cascade
Definition: A MAPK cascade containing at least the JNK (MAPK8) MAP kinase. It starts with the activation of JUN3K (a MAPK3K), which activates JNKK a MAP2K), which in turn activates JNK. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier. The JNK cascade is activated by stress signals, as well as by G protein-coupled receptors, growth factors, and cytokines, and results in cellular responses such as cell proliferation, cell differentiation, apoptosis and inflammation.
Definition Source(s): PMID:11790549, PMID:20811974, PMID:23125017
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK8involved_inIBAFB:FBgn0000229 or MGI:1346861 or MGI:1346863 or PANTHER:PTN001171982 or Mapk10 (Rattus norvegicus) or Mapk9 (Rattus norvegicus) or UniProtKB:P45983 or UniProtKB:P45984 or WB:WBGene00002178 or WB:WBGene00002187 or ZFIN:ZDB-GENE-010202-1150520179GO_Central GO_REF:0000033
MAPK8involved_inIEAPANTHER:PTHR24055:SF222150520179TreeGrafter GO_REF:0000118
MAPK8involved_inIDA 150520179UniProt PMID:8654373

PMID:8654373
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