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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732271
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:4027
Term: cyclophosphamide
Definition: A phosphorodiamide that is 1,3,2-oxazaphosphinan-2-amine 2-oxide substituted by two 2-chloroethyl groups at the amino nitrogen atom.
Chemical ID: MESH:D003520
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK8increases phosphorylationISOMapk8 (Mus musculus)6480464CTDCyclophosphamide results in increased phosphorylation of MAPK8 proteinPMID:19696094
MAPK8multiple interactionsISOMapk8 (Rattus norvegicus)6480464CTDCyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK8 protein; NGF protein affects the reaction [Cyclophosphamide results in increased phosphorylation of and results in increased activity of MAPK8 protein]PMID:19996110
MAPK8multiple interactionsISOMapk8 (Mus musculus)6480464CTDGSTP1 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; GSTP2 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; Mesna inhibits the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]; Mesna inhibits the reaction [GSTP1 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]]; Mesna inhibits the reaction [GSTP2 protein affects the reaction [Cyclophosphamide results in increased phosphorylation of MAPK8 protein]]PMID:19696094
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