GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | MAPK8 | affects response to substance | EXP | | 6480464 | CTD | MAPK8 protein affects the susceptibility to resveratrol | PMID:20082299 | MAPK8 | decreases activity | EXP | | 6480464 | CTD | resveratrol results in decreased activity of MAPK8 protein | PMID:11408617 | MAPK8 | decreases expression | EXP | | 6480464 | CTD | resveratrol results in decreased expression of MAPK8 protein | PMID:18089832 | MAPK8 | decreases phosphorylation | EXP | | 6480464 | CTD | resveratrol results in decreased phosphorylation of MAPK8 protein | PMID:23437203 | MAPK8 | increases phosphorylation | EXP | | 6480464 | CTD | resveratrol results in increased phosphorylation of MAPK8 protein | PMID:18347188 | MAPK8 | multiple interactions | EXP | | 6480464 | CTD | [Plant Extracts co-treated with Resveratrol] results in increased expression of MAPK8 mRNA; MAPK8 protein affects the reaction [Resveratrol results in increased expression of PRF1 protein]; pyrazolanthrone inhibits the reaction [Resveratrol results in increased phosphorylation of MAPK8 protein]; Resveratrol results in increased phosphorylation of and results in increased activity of MAPK8 protein | PMID:15217905 PMID:18222423 PMID:18347188 PMID:20082299 PMID:23557933 | MAPK8 | decreases expression | ISO | Mapk8 (Rattus norvegicus) | 6480464 | CTD | resveratrol results in decreased expression of MAPK8 protein modified form | PMID:27093858 | MAPK8 | increases activity | ISO | Mapk8 (Mus musculus) | 6480464 | CTD | resveratrol results in increased activity of MAPK8 protein | PMID:11933078 PMID:21679764 | MAPK8 | multiple interactions | ISO | Mapk8 (Rattus norvegicus) | 6480464 | CTD | [Resveratrol co-treated with Ramipril] inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein]; dorsomorphin inhibits the reaction [Resveratrol results in decreased expression of MAPK8 protein modified form]; Resveratrol inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of MAPK8 protein modified form]; Resveratrol inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]; Resveratrol inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK8 protein] | PMID:27093858 PMID:31062909 PMID:31433112 | MAPK8 | multiple interactions | ISO | Mapk8 (Mus musculus) | 6480464 | CTD | [resveratrol results in increased activity of MAPK8 protein] which results in increased phosphorylation of and results in increased activity of TRP53 protein; resveratrol inhibits the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of and results in increased activity of MAPK8 protein]; resveratrol inhibits the reaction [Acetaminophen results in increased phosphorylation of MAPK8 protein]; resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK8 protein]; resveratrol inhibits the reaction [Excitatory Amino Acid Agents results in increased phosphorylation of and results in increased activity of MAPK8 protein] | PMID:11933078 PMID:16322078 PMID:20542495 PMID:24333336 PMID:25956474 | | ||||||||||||||||||||||
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