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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732271
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK8increases expressionEXP 6480464CTDQuercetin results in increased expression of MAPK8 mRNA; Quercetin results in increased expression of MAPK8 protein modified formPMID:19017364 PMID:23727915
MAPK8increases phosphorylationEXP 6480464CTDQuercetin results in increased phosphorylation of MAPK8 proteinPMID:18377872 PMID:24647664 PMID:25293876
MAPK8multiple interactionsEXP 6480464CTD[Ellagic Acid co-treated with Quercetin] results in increased phosphorylation of MAPK8 protein; HSPA5 protein inhibits the reaction [Quercetin results in increased expression of MAPK8 protein modified form]; Quercetin inhibits the reaction [APP protein results in increased phosphorylation of and results in increased activity of MAPK8 protein]; Quercetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Quercetin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK8 protein]; Quercetin inhibits the reaction [TNF protein results in increased phosphorylation of MAPK8 protein]; Quercetin results in decreased phosphorylation of and results in decreased activity of MAPK8 proteinPMID:10718847 PMID:15735102 PMID:15795422 PMID:19017364 PMID:19464278 PMID:22452660 PMID:22592909
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