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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732271
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK8
Name: mitogen-activated protein kinase 8
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK8increases phosphorylationEXP 6480464CTDEthanol results in increased phosphorylation of MAPK8 proteinPMID:28062356 PMID:32237978
MAPK8multiple interactionsEXP 6480464CTDMAPK8 promotes the reaction [Ethanol results in increased expression of and results in increased activity of RUNX2 protein]PMID:32198086
MAPK8increases phosphorylationISOMapk8 (Rattus norvegicus)6480464CTDEthanol results in increased phosphorylation of MAPK8 proteinPMID:19735724
MAPK8increases phosphorylationISOMapk8 (Mus musculus)6480464CTDEthanol results in increased phosphorylation of MAPK8 proteinPMID:28119953 PMID:29044621
MAPK8multiple interactionsISOMapk8 (Rattus norvegicus)6480464CTDPolysaccharides inhibits the reaction [Ethanol results in increased phosphorylation of MAPK8 protein]PMID:19735724
MAPK8multiple interactionsISOMapk8 (Mus musculus)6480464CTD[Bicuculline co-treated with Ethanol] results in increased expression of MAPK8 protein; gamma-Aminobutyric Acid inhibits the reaction [Ethanol results in increased expression of MAPK8 protein]; Muscimol inhibits the reaction [Ethanol results in increased expression of MAPK8 protein]PMID:29044621
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