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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732257
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTP1
Name: glutathione S-transferase pi 1
Acc ID: CHEBI:47807
Term: sulforaphane
Definition: An isothiocyanate having a 4-(methylsulfinyl)butyl group attached to the nitrogen.
Chemical ID: MESH:C016766
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTP1affects bindingEXP 6480464CTDGSTP1 protein binds to sulforaphanePMID:21838287
GSTP1affects metabolic processingEXP 6480464CTDGSTP1 protein affects the metabolism of sulforaphanePMID:7826396
GSTP1decreases activityEXP 6480464CTDsulforaphane results in decreased activity of GSTP1 proteinPMID:17937621
GSTP1increases expressionISOGstp1 (Mus musculus)6480464CTDsulforaphane results in increased expression of GSTP1 mRNA; sulforaphane results in increased expression of GSTP1 proteinPMID:19303893 PMID:20932822
GSTP1increases expressionISOGstp1 (Rattus norvegicus)6480464CTDsulforaphane results in increased expression of GSTP1 mRNAPMID:20237067 PMID:21871945
GSTP1multiple interactionsISOGstp1 (Mus musculus)6480464CTDNFE2L2 protein promotes the reaction [sulforaphane results in increased expression of GSTP1 mRNA]PMID:20932822
GSTP1multiple interactionsISOGstp1 (Rattus norvegicus)6480464CTD[sulforaphane promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; [sulforaphane promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA; N-Methyl-3,4-methylenedioxyamphetamine inhibits the reaction [sulforaphane results in increased expression of GSTP1 mRNA]; sulforaphane inhibits the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of GSTP1 mRNA]; sulforaphane promotes the reaction [JUN protein binds to GSTP1 enhancer]; sulforaphane promotes the reaction [NFE2L2 protein binds to GSTP1 enhancer]; sulforaphane results in increased expression of and results in increased activity of GSTP1 proteinPMID:20237067 PMID:21871945
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