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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732257
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTP1
Name: glutathione S-transferase pi 1
Acc ID: CHEBI:25812
Term: ozone
Definition: An elemental molecule with formula O3. An explosive, pale blue gas (b.p. -112degreeC) that has a characteristic, pungent odour, it is continuously produced in the upper atmosphere by the action of solar ultraviolet radiation on atmospheric oxygen. It is an antimicrobial agent used in the production of bottled water, as well as in the treatment of meat, poultry and other foodstuffs.
Chemical ID: MESH:D010126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTP1affects response to substanceEXP 6480464CTDGSTP1 gene polymorphism affects the susceptibility to OzonePMID:22732554
GSTP1increases response to substanceEXP 6480464CTDGSTP1 gene SNP results in increased susceptibility to OzonePMID:16870661 PMID:17652311 PMID:18524839
GSTP1multiple interactionsEXP 6480464CTDGSTP1 gene SNP affects the reaction [MS4A2 gene SNP affects the susceptibility to Ozone]; GSTP1 gene SNP affects the reaction [TNF gene SNP affects the susceptibility to Ozone]; GSTP1 gene SNP promotes the reaction [HMOX1 gene SNP results in increased susceptibility to Ozone]PMID:16456144 PMID:18269668 PMID:18524839
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