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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732246
Species: Homo sapiens
RGD Object: Gene
Symbol: CNR2
Name: cannabinoid receptor 2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CNR2increases methylationEXP 6480464CTDBenzo(a)pyrene results in increased methylation of CNR2 3' UTR; Benzo(a)pyrene results in increased methylation of CNR2 5' UTRPMID:27901495
CNR2increases mutagenesisEXP 6480464CTDBenzo(a)pyrene results in increased mutagenesis of CNR2 genePMID:25435355
CNR2increases expressionISOCnr2 (Mus musculus)6480464CTDBenzo(a)pyrene results in increased expression of CNR2 mRNA; Benzo(a)pyrene results in increased expression of CNR2 proteinPMID:22228805 PMID:27329536
CNR2multiple interactionsISOCnr2 (Mus musculus)6480464CTD[Lipopolysaccharides co-treated with Benzo(a)pyrene] results in increased expression of CNR2 protein; Docosahexaenoic Acids promotes the reaction [[Lipopolysaccharides co-treated with Benzo(a)pyrene] results in increased expression of CNR2 protein]; Docosahexaenoic Acids promotes the reaction [Benzo(a)pyrene results in increased expression of CNR2 protein]PMID:27329536
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