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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732227
Species: Homo sapiens
RGD Object: Gene
Symbol: NR3C1
Name: nuclear receptor subfamily 3 group C member 1
Acc ID: CHEBI:5134
Term: fluticasone
Definition: A trifluorinated corticosteroid used in the form of its propionate ester for treatment of allergic rhinitis.
Chemical ID: MESH:C065382
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR3C1affects bindingEXP 6480464CTDFluticasone binds to NR3C1 proteinPMID:7878687
NR3C1affects localizationEXP 6480464CTDFluticasone affects the localization of NR3C1 proteinPMID:15860753
NR3C1multiple interactionsEXP 6480464CTD[Fluticasone co-treated with Salmeterol Xinafoate] affects the localization of and results in increased activity of NR3C1 protein; [Fluticasone co-treated with Salmeterol Xinafoate] affects the localization of NR3C1 protein; [Fluticasone co-treated with Tetradecanoylphorbol Acetate] affects the localization of NR3C1 protein; Fluticasone affects the localization of and results in increased activity of NR3C1 protein; Fluticasone promotes the reaction [15-deoxyprostaglandin J2 promotes the reaction [NR3C1 protein binds to PPARG protein]]; Salmeterol Xinafoate promotes the reaction [[Fluticasone co-treated with Tetradecanoylphorbol Acetate] affects the localization of NR3C1 protein]; Salmeterol Xinafoate promotes the reaction [Fluticasone affects the localization of and results in increased activity of NR3C1 protein]; Salmeterol Xinafoate promotes the reaction [Fluticasone affects the localization of NR3C1 protein]PMID:15531761 PMID:15536434 PMID:15860753 PMID:15862954
NR3C1affects bindingISONr3c1 (Rattus norvegicus)6480464CTDFluticasone binds to NR3C1 proteinPMID:15878996 PMID:16507850
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