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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732227
Species: Homo sapiens
RGD Object: Gene
Symbol: NR3C1
Name: nuclear receptor subfamily 3 group C member 1
Acc ID: CHEBI:3001
Term: beclomethasone
Definition: A 17alpha-hydroxy steroid that is prednisolone in which the hydrogens at the 9alpha and 16beta positions are substituted by a chlorine and a methyl group, respectively.
Chemical ID: MESH:D001507
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR3C1affects bindingEXP 6480464CTDBeclomethasone binds to NR3C1 proteinPMID:16507850
NR3C1affects localizationEXP 6480464CTDBeclomethasone affects the localization of NR3C1 proteinPMID:15860753
NR3C1increases activityEXP 6480464CTDBeclomethasone results in increased activity of NR3C1 proteinPMID:15362971 PMID:21543282
NR3C1increases expressionEXP 6480464CTDBeclomethasone results in increased expression of NR3C1 mRNAPMID:24555085
NR3C1multiple interactionsEXP 6480464CTD[Beclomethasone co-treated with Albuterol] affects the localization of NR3C1 protein; [Beclomethasone co-treated with Formoterol Fumarate] affects the localization of NR3C1 protein; Beclomethasone affects the localization of and results in increased activity of NR3C1 protein; Beclomethasone binds to and results in increased activity of NR3C1 proteinPMID:15679717 PMID:15862954 PMID:2207292
NR3C1affects bindingISONr3c1 (Rattus norvegicus)6480464CTDBeclomethasone binds to NR3C1 proteinPMID:16814
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