GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gsr | decreases activity | EXP | | 6480464 | CTD | bisphenol A results in decreased activity of GSR protein | PMID:21840368 PMID:22269103 | Gsr | increases expression | EXP | | 6480464 | CTD | bisphenol A results in increased expression of GSR mRNA | PMID:26049153 PMID:37510359 | Gsr | increases response to substance | EXP | | 6480464 | CTD | GSR protein results in increased susceptibility to bisphenol A | PMID:37510359 | Gsr | multiple interactions | EXP | | 6480464 | CTD | Ginsenosides inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; GSR protein affects the reaction [bisphenol A results in increased expression of CCL2 mRNA]; GSR protein affects the reaction [bisphenol A results in increased expression of IL1B mRNA]; GSR protein affects the reaction [bisphenol A results in increased expression of IL6 mRNA]; Melatonin inhibits the reaction [bisphenol A results in decreased activity of GSR protein] | PMID:21840368 PMID:22269103 PMID:37510359 | Gsr | affects expression | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | bisphenol A affects the expression of GSR mRNA | PMID:25181051 | Gsr | affects expression | ISO | GSR (Homo sapiens) | 6480464 | CTD | bisphenol A affects the expression of GSR mRNA | PMID:30903817 | Gsr | decreases activity | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | bisphenol A results in decreased activity of GSR protein | PMID:12767684 PMID:22623521 PMID:22888396 | Gsr | decreases expression | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | bisphenol A results in decreased expression of GSR mRNA; bisphenol A results in decreased expression of GSR protein | PMID:22888396 PMID:30816183 PMID:32528016 PMID:35465754 | Gsr | decreases expression | ISO | GSR (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased expression of GSR protein | PMID:31675489 PMID:34186270 | Gsr | decreases methylation | ISO | GSR (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased methylation of GSR promoter | PMID:30352284 | Gsr | increases expression | ISO | GSR (Homo sapiens) | 6480464 | CTD | bisphenol A results in increased expression of GSR mRNA; bisphenol A results in increased expression of GSR protein | PMID:29275510 PMID:32244372 PMID:37567409 | Gsr | increases methylation | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | bisphenol A results in increased methylation of GSR gene | PMID:28505145 | Gsr | multiple interactions | ISO | Gsr (Rattus norvegicus) | 6480464 | CTD | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in increased expression of GSR mRNA; Ascorbic Acid inhibits the reaction [bisphenol A results in decreased activity of GSR protein]; Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]; Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]]; taxifolin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]; taxifolin promotes the reaction [Fluvastatin inhibits the reaction [bisphenol A results in decreased expression of GSR protein]]; Thioctic Acid inhibits the reaction [bisphenol A results in decreased activity of GSR protein] | PMID:12767684 PMID:22623521 PMID:35465754 PMID:36041667 | Gsr | multiple interactions | ISO | GSR (Homo sapiens) | 6480464 | CTD | [bisphenol A co-treated with cylindrospermopsin] results in increased expression of GSR mRNA | PMID:32244372 | | ||||||||||||||||||||||
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