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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732222
Species: Mus musculus
RGD Object: Gene
Symbol: Gsr
Name: glutathione reductase
Acc ID: CHEBI:17356
Term: 2-acetamidofluorene
Definition: The parent of the class of 2-acetamidofluorenes, being an ortho-fused polycyclic arene that consists of 9H-fluorene bearing an acetamido substituent at position 2. It is a carcinogenic and mutagenic derivative of fluorene.
Chemical ID: MESH:D015073
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gsrdecreases activityISOGsr (Rattus norvegicus)6480464CTD2-Acetylaminofluorene results in decreased activity of GSR proteinPMID:26364502
Gsrdecreases expressionISOGsr (Rattus norvegicus)6480464CTD2-Acetylaminofluorene results in decreased expression of GSR proteinPMID:23665045
Gsrmultiple interactionsISOGsr (Rattus norvegicus)6480464CTD[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of GSR mRNA; Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]; geraniol inhibits the reaction [2-Acetylaminofluorene results in decreased activity of GSR protein]PMID:16158176 PMID:23665045 PMID:26364502
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