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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732220
Species: Mus musculus
RGD Object: Gene
Symbol: Abcg5
Name: ATP binding cassette subfamily G member 5
Acc ID: CHEBI:64294
Term: 7-ketocholesterol
Definition: A cholestanoid that consists of cholesterol bearing an oxo substituent at position 7.
Chemical ID: MESH:C003001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcg5decreases expressionISOABCG5 (Homo sapiens)6480464CTD7-ketocholesterol results in decreased expression of ABCG5 mRNAPMID:23454145
Abcg5multiple interactionsISOABCG5 (Homo sapiens)6480464CTD[7-ketocholesterol co-treated with KNG1 protein modified form] results in decreased expression of ABCG5 mRNA; [7-ketocholesterol co-treated with Oligomycins] results in decreased expression of ABCG5 mRNA; [7-ketocholesterol co-treated with Rotenone] results in decreased expression of ABCG5 mRNAPMID:23454145
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