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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732213
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp8b1
Name: cytochrome P450, family 8, subfamily b, polypeptide 1
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp8b1decreases expressionEXP 6480464CTDLithocholic Acid results in decreased expression of CYP8B1 mRNAPMID:16436656 PMID:19196849 PMID:20359477 PMID:25582706
Cyp8b1multiple interactionsEXP 6480464CTD1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]; NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]; NR1I3 protein promotes the reaction [Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]]; Phenobarbital inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [Lithocholic Acid results in decreased expression of CYP8B1 mRNA]PMID:19196849 PMID:20359477
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