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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732196
Species: Homo sapiens
RGD Object: Gene
Symbol: FOSL1
Name: FOS like 1, AP-1 transcription factor subunit
Acc ID: CHEBI:46666
Term: crocidolite asbestos
Definition: null
Chemical ID: MESH:D017638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FOSL1affects expressionEXP 6480464CTDAsbestos, Crocidolite affects the expression of FOSL1 mRNAPMID:25757056
FOSL1increases expressionEXP 6480464CTDAsbestos, Crocidolite results in increased expression of FOSL1 mRNA; Asbestos, Crocidolite results in increased expression of FOSL1 proteinPMID:12839939 PMID:18687144 PMID:25351596
FOSL1multiple interactionsEXP 6480464CTDFOSL1 protein promotes the reaction [Asbestos, Crocidolite results in increased expression of CD44 mRNA]; FOSL1 protein promotes the reaction [Asbestos, Crocidolite results in increased expression of MET mRNA]PMID:12839939
FOSL1increases expressionISOFosl1 (Mus musculus)6480464CTDAsbestos, Crocidolite results in increased expression of FOSL1 mRNAPMID:14737115 PMID:15520183 PMID:23917077
FOSL1increases expressionISOFosl1 (Rattus norvegicus)6480464CTDAsbestos, Crocidolite results in increased expression of FOSL1 mRNAPMID:10783328 PMID:12839939 PMID:17616677
FOSL1multiple interactionsISOFosl1 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]; [GCLC protein co-treated with GCLM protein] inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]; Acetylcysteine inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]; AG 1879 inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]; Buthionine Sulfoximine promotes the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]; GCLM protein inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]; Glutathione inhibits the reaction [Asbestos, Crocidolite results in increased expression of FOSL1 mRNA]PMID:14737115 PMID:15520183
FOSL1multiple interactionsISOFosl1 (Rattus norvegicus)6480464CTDFOSL1 protein promotes the reaction [Asbestos, Crocidolite results in increased expression of CD44 mRNA]; FOSL1 protein promotes the reaction [Asbestos, Crocidolite results in increased expression of MET mRNA]PMID:12839939
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