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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732185
Species: Mus musculus
RGD Object: Gene
Symbol: Stat1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:16240
Term: hydrogen peroxide
Definition: An inorganic peroxide consisting of two hydroxy groups joined by a covalent oxygen-oxygen single bond.
Chemical ID: MESH:D006861
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Stat1multiple interactionsEXP 6480464CTDHydrogen Peroxide inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]PMID:12847270
Stat1affects localizationISOSTAT1 (Homo sapiens)6480464CTDHydrogen Peroxide affects the localization of STAT1 proteinPMID:10364193
Stat1increases phosphorylationISOStat1 (Rattus norvegicus)6480464CTDHydrogen Peroxide results in increased phosphorylation of STAT1 proteinPMID:17607690
Stat1multiple interactionsISOStat1 (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of STAT1 protein]; alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of STAT1 protein]PMID:17607690
Stat1multiple interactionsISOSTAT1 (Homo sapiens)6480464CTDHydrogen Peroxide affects the reaction [vanadium pentoxide results in increased phosphorylation of and results in increased activity of STAT1 protein]; Hydrogen Peroxide inhibits the reaction [CNTF protein results in increased phosphorylation of and results in increased activity of STAT1 protein]; Hydrogen Peroxide inhibits the reaction [CNTF results in increased phosphorylation of STAT1 protein]; Hydrogen Peroxide inhibits the reaction [IFNG protein affects the localization of STAT1 protein]; Hydrogen Peroxide inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]PMID:15748169 PMID:18322232 PMID:19635391
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