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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732184
Species: Homo sapiens
RGD Object: Gene
Symbol: STAT1
Name: signal transducer and activator of transcription 1
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
STAT1increases expressionISOStat1 (Rattus norvegicus)6480464CTDChlorpyrifos results in increased expression of STAT1 proteinPMID:29859868
STAT1multiple interactionsISOStat1 (Rattus norvegicus)6480464CTDacetovanillone analog inhibits the reaction [Chlorpyrifos results in increased expression of and results in increased phosphorylation of STAT1 protein]; Chlorpyrifos promotes the reaction [STAT1 protein binds to BAX promoter]; Chlorpyrifos promotes the reaction [STAT1 protein binds to NOX1 promoter]; Chlorpyrifos results in increased activity of and results in increased phosphorylation of STAT1 protein; Chlorpyrifos results in increased expression of and results in increased phosphorylation of STAT1 protein; STAT1 protein affects the reaction [Chlorpyrifos results in decreased expression of BCL2 protein]; STAT1 protein affects the reaction [Chlorpyrifos results in increased activity of CASP3 protein]; STAT1 protein affects the reaction [Chlorpyrifos results in increased cleavage of PARP1 protein]; STAT1 protein affects the reaction [Chlorpyrifos results in increased expression of BAX protein]; STAT1 protein affects the reaction [Chlorpyrifos results in increased expression of BECN1 protein]; STAT1 protein affects the reaction [Chlorpyrifos results in increased expression of NOX1 protein]; STAT1 protein affects the reaction [Chlorpyrifos results in increased expression of SQSTM1 protein]; STAT1 protein affects the reaction [Chlorpyrifos results in increased lipidation of MAP1LC3B protein]; STAT1 protein promotes the reaction [Chlorpyrifos results in increased cleavage of PRKCD protein]PMID:29859868
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