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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732177
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcr4
Name: C-X-C motif chemokine receptor 4
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcr4increases expression ISOCXCR4 (Homo sapiens)152025558RGD17beta-estradiol increases expression of CXCR4 protein in multiple cells 
Cxcr4increases expressionEXP 6480464CTDEstradiol results in increased expression of CXCR4 proteinPMID:17578864
Cxcr4decreases expressionISOCXCR4 (Homo sapiens)6480464CTDEstradiol results in decreased expression of CXCR4 mRNAPMID:19619570 PMID:24758408
Cxcr4decreases response to substanceISOCXCR4 (Homo sapiens)6480464CTDCXCR4 protein results in decreased susceptibility to EstradiolPMID:22549810
Cxcr4increases expressionISOCXCR4 (Homo sapiens)6480464CTDEstradiol results in increased expression of CXCR4 mRNA; Estradiol results in increased expression of CXCR4 proteinPMID:28844962 PMID:29654831
Cxcr4multiple interactionsISOCxcr4 (Rattus norvegicus)6480464CTD[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of CXCR4 mRNAPMID:32741896
Cxcr4multiple interactionsISOCXCR4 (Homo sapiens)6480464CTD3,3'-diindolylmethane inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]; [Estradiol co-treated with EGF protein] results in increased expression of CXCR4 mRNA; [Estradiol co-treated with Progesterone] results in decreased expression of CXCR4 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of CXCR4 mRNA; EGF protein inhibits the reaction [Estradiol results in decreased expression of CXCR4 mRNA]; Fingolimod Hydrochloride inhibits the reaction [Estradiol results in increased expression of CXCR4 mRNA]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]; plerixafor inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]PMID:19619570 PMID:20660070 PMID:24758408 PMID:28844962 PMID:29654831
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