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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732160
Species: Mus musculus
RGD Object: Gene
Symbol: Pdcd4
Name: programmed cell death 4
Acc ID: CHEBI:33007
Term: chromium(6+)
Definition: A monoatomic hexacation that has formula Cr.
Chemical ID: MESH:C074702
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pdcd4decreases expressionEXP 6480464CTDchromium hexavalent ion results in decreased expression of PDCD4 proteinPMID:27323401
Pdcd4decreases expressionISOPDCD4 (Homo sapiens)6480464CTDchromium hexavalent ion results in decreased expression of PDCD4; chromium hexavalent ion results in decreased expression of PDCD4 mRNA; chromium hexavalent ion results in decreased expression of PDCD4 proteinPMID:27323401 PMID:27344173 PMID:28881718
Pdcd4multiple interactionsISOPDCD4 (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [chromium hexavalent ion results in decreased expression of PDCD4 mRNA]; CAT protein inhibits the reaction [chromium hexavalent ion results in decreased expression of PDCD4 mRNA]; CAT protein inhibits the reaction [chromium hexavalent ion results in decreased expression of PDCD4 protein]; MIR21 mRNA affects the reaction [chromium hexavalent ion results in decreased expression of PDCD4 protein]; Quercetin inhibits the reaction [chromium hexavalent ion results in decreased expression of PDCD4 protein]; Quercetin inhibits the reaction [chromium hexavalent ion results in decreased expression of PDCD4]PMID:27323401 PMID:27344173 PMID:28881718
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