GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Kcnh2 | affects folding | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | Potassium deficiency affects the folding of KCNH2 protein | PMID:19139152 | Kcnh2 | increases transport | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | KCNH2 protein results in increased transport of Potassium | PMID:11805215 PMID:12359267 PMID:17624316 PMID:19419905 | Kcnh2 | multiple interactions | ISO | KCNH2 (Homo sapiens) | 6480464 | CTD | [[Colforsin co-treated with 1-Methyl-3-isobutylxanthine] results in increased activity of [ADRB1 protein binds to ADRB2 protein]] affects the reaction [KCNH2 protein results in increased transport of Potassium]; [Gatifloxacin binds to and results in decreased activity of KCNH2 protein] which results in decreased export of Potassium; [Hydroxychloroquine binds to and results in decreased activity of KCNH2 protein] which results in decreased export of Potassium; [iron(III)-ascorbic acid complex results in increased abundance of Reactive Oxygen Species] affects the reaction [KCNH2 protein affects the transport of Potassium]; [KCNH2 protein binds to KCNE2 protein] which results in increased transport of Potassium; [KCNH2 protein binds to KCNH2 protein] which results in increased transport of Potassium; E 4031 inhibits the reaction [Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]]; E 4031 inhibits the reaction [Niflumic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]]; Flufenamic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]; Fluoxetine inhibits the reaction [KCNH2 protein results in increased transport of Potassium]; Niflumic Acid promotes the reaction [KCNH2 protein results in increased transport of Potassium]; Phenylephrine affects the reaction [KCNH2 protein results in increased transport of Potassium]; Potassium affects the reaction [dofetilide analog inhibits the reaction [dofetilide binds to KCNH2 protein]]; Potassium affects the stability of and affects the localization of KCNH2 protein modified form; Potassium inhibits the reaction [Amiodarone results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [azimilide results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [dofetilide results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [Dronedarone results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [Gramicidin results in decreased expression of KCNH2 protein modified form]; Potassium inhibits the reaction [Quinidine results in decreased activity of KCNH2 protein]; Potassium inhibits the reaction [Sotalol results in decreased activity of KCNH2 protein]; Potassium promotes the reaction [Astemizole binds to KCNH2 protein]; Potassium promotes the reaction [dofetilide binds to KCNH2 protein] | PMID:11805215 PMID:12359267 PMID:15618689 PMID:15679475 PMID:16960444 PMID:19139152 PMID:19419905 PMID:24200993 PMID:34058295 PMID:9326673 | | ||||||||||||||||||||||
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