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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732101
Species: Homo sapiens
RGD Object: Gene
Symbol: KCNH2
Name: potassium voltage-gated channel subfamily H member 2
Acc ID: CHEBI:45081
Term: pentamidine
Definition: A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Chemical ID: MESH:D010419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
KCNH2decreases activityEXP 6480464CTDPentamidine results in decreased activity of KCNH2 proteinPMID:21158687
KCNH2multiple interactionsEXP 6480464CTDPentamidine affects the localization of and affects the activity of KCNH2 protein; Pentamidine affects the localization of and results in decreased activity of KCNH2 protein; Pentamidine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]PMID:15340016 PMID:15711590 PMID:21158687
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