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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732095
Species: Mus musculus
RGD Object: Gene
Symbol: Pcna
Name: proliferating cell nuclear antigen
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pcnadecreases expressionEXP 6480464CTDGenistein results in decreased expression of PCNA mRNAPMID:21048042
Pcnaincreases expressionEXP 6480464CTDGenistein results in increased expression of PCNA mRNA; Genistein results in increased expression of PCNA proteinPMID:10965916 PMID:16985261
Pcnadecreases expressionISOPcna (Rattus norvegicus)6480464CTDGenistein results in decreased expression of PCNA; Genistein results in decreased expression of PCNA mRNA; Genistein results in decreased expression of PCNA proteinPMID:12929590 PMID:17049845
Pcnadecreases expressionISOPCNA (Homo sapiens)6480464CTDGenistein results in decreased expression of PCNA; Genistein results in decreased expression of PCNA proteinPMID:16149052 PMID:21161820
Pcnaincreases expressionISOPcna (Rattus norvegicus)6480464CTDGenistein results in increased expression of PCNA mRNA; Genistein results in increased expression of PCNA proteinPMID:21782745 PMID:29217487
Pcnaincreases expressionISOPCNA (Homo sapiens)6480464CTDGenistein results in increased expression of PCNA mRNAPMID:16474171 PMID:22228119
Pcnamultiple interactionsISOPCNA (Homo sapiens)6480464CTD[Genistein co-treated with Lapatinib] affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; Genistein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]; Genistein affects the reaction [ERBB2 protein affects the reaction [[sodium arsenite results in increased abundance of Arsenic] which affects the expression of PCNA protein]]PMID:33396024
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