Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732084
Species: Homo sapiens
RGD Object: Gene
Symbol: CTH
Name: cystathionine gamma-lyase
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CTHdecreases expressionEXP 6480464CTDLipopolysaccharides results in decreased expression of CTH mRNA; Lipopolysaccharides results in decreased expression of CTH proteinPMID:29128401
CTHmultiple interactionsEXP 6480464CTDTLR4 mRNA promotes the reaction [Lipopolysaccharides results in decreased expression of CTH protein]PMID:29128401
CTHdecreases expressionISOCth (Rattus norvegicus)6480464CTDLipopolysaccharides results in decreased expression of CTH proteinPMID:21308383
CTHincreases expressionISOCth (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased expression of CTH mRNAPMID:16491094
CTHincreases response to substanceISOCth (Mus musculus)6480464CTDCTH protein mutant form results in increased susceptibility to LipopolysaccharidesPMID:29128401
CTHmultiple interactionsISOCth (Rattus norvegicus)6480464CTD[Lipopolysaccharides results in decreased expression of CTH protein] which results in decreased chemical synthesis of Hydrogen Sulfide; Cysteine analog promotes the reaction [[Lipopolysaccharides results in decreased expression of CTH protein] which results in decreased chemical synthesis of Hydrogen Sulfide]; nitroflurbiprofen inhibits the reaction [Lipopolysaccharides results in increased expression of CTH mRNA]PMID:16491094 PMID:21308383
CTHmultiple interactionsISOCth (Mus musculus)6480464CTD[CTH protein mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL4 mRNA; [CTH protein mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL4 protein; [CTH protein mutant form results in increased susceptibility to Lipopolysaccharides] which results in increased expression of IL6 protein; CTH protein mutant form promotes the reaction [Lipopolysaccharides results in increased expression of IL2 mRNA]; CTH protein mutant form promotes the reaction [Lipopolysaccharides results in increased expression of IL2 protein]; CTH protein mutant form promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; CTH protein mutant form promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; CTH protein mutant form promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Lipopolysaccharides promotes the reaction [CTH protein mutant form results in increased expression of IL2 mRNA]; Lipopolysaccharides promotes the reaction [CTH protein mutant form results in increased expression of IL2 protein]; Lipopolysaccharides promotes the reaction [CTH protein mutant form results in increased expression of IL4 mRNA]; Lipopolysaccharides promotes the reaction [CTH protein mutant form results in increased expression of IL4 protein]; Lipopolysaccharides promotes the reaction [CTH protein mutant form results in increased expression of IL6 mRNA]PMID:29128401
Go Back to source page   Continue to Ontology report