GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | MAP2K1 | decreases expression | EXP | | 6480464 | CTD | Doxorubicin results in decreased expression of MAP2K1 mRNA | PMID:29803840 | MAP2K1 | increases phosphorylation | EXP | | 6480464 | CTD | Doxorubicin results in increased phosphorylation of MAP2K1 protein | PMID:17974986 | MAP2K1 | multiple interactions | EXP | | 6480464 | CTD | [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] affects the reaction [SOD2 protein results in decreased susceptibility to Doxorubicin]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [SOD2 protein affects the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased activity of MAP2K1 protein] inhibits the reaction [SOD2 protein affects the reaction [Doxorubicin results in increased cleavage of CASP9 protein]] | PMID:18594523 | MAP2K1 | increases phosphorylation | ISO | Map2k1 (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased phosphorylation of MAP2K1 protein | PMID:17974986 | | ||||||||||||||||||||||
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