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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732023
Species: Homo sapiens
RGD Object: Gene
Symbol: MAP2K1
Name: mitogen-activated protein kinase kinase 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAP2K1increases phosphorylationEXP 6480464CTDLipopolysaccharides results in increased phosphorylation of MAP2K1 proteinPMID:19010997
MAP2K1multiple interactionsEXP 6480464CTDMAP2K1 protein mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]PMID:18209571
MAP2K1increases expressionISOMap2k1 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of MAP2K1 mRNAPMID:10975854
MAP2K1increases phosphorylationISOMap2k1 (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased phosphorylation of MAP2K1 proteinPMID:21247645
MAP2K1multiple interactionsISOMap2k1 (Mus musculus)6480464CTD[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein; Ketamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP2K1 protein]; Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP2K1 protein; MAP2K1 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]; MAP2K1 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein]PMID:19540866 PMID:21295571 PMID:23362215
MAP2K1multiple interactionsISOMap2k1 (Rattus norvegicus)6480464CTDMAP2K1 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; MAP2K1 protein promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; rosiglitazone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K1 protein]PMID:10469353 PMID:21247645
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