GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | MAP2K1 | increases phosphorylation | EXP | | 6480464 | CTD | Lipopolysaccharides results in increased phosphorylation of MAP2K1 protein | PMID:19010997 | MAP2K1 | multiple interactions | EXP | | 6480464 | CTD | MAP2K1 protein mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] | PMID:18209571 | MAP2K1 | increases expression | ISO | Map2k1 (Mus musculus) | 6480464 | CTD | Lipopolysaccharides results in increased expression of MAP2K1 mRNA | PMID:10975854 | MAP2K1 | increases phosphorylation | ISO | Map2k1 (Rattus norvegicus) | 6480464 | CTD | Lipopolysaccharides results in increased phosphorylation of MAP2K1 protein | PMID:21247645 | MAP2K1 | multiple interactions | ISO | Map2k1 (Mus musculus) | 6480464 | CTD | [Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein; Ketamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP2K1 protein]; Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP2K1 protein; MAP2K1 protein promotes the reaction [Lipopolysaccharides inhibits the reaction [TGFB1 protein results in increased expression of SMAD6 mRNA]]; MAP2K1 protein promotes the reaction [Lipopolysaccharides results in increased phosphorylation of SMAD3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein] | PMID:19540866 PMID:21295571 PMID:23362215 | MAP2K1 | multiple interactions | ISO | Map2k1 (Rattus norvegicus) | 6480464 | CTD | MAP2K1 protein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; MAP2K1 protein promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; rosiglitazone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAP2K1 protein] | PMID:10469353 PMID:21247645 | |
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