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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731977
Species: Mus musculus
RGD Object: Gene
Symbol: Cflar
Name: CASP8 and FADD-like apoptosis regulator
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cflarincreases expressionISOCFLAR (Homo sapiens)6480464CTDTretinoin results in increased expression of CFLAR mRNAPMID:21934132 PMID:33167477
Cflarmultiple interactionsISOCFLAR (Homo sapiens)6480464CTD[Tretinoin co-treated with TGFB1 protein] results in increased expression of CFLAR protein; Tretinoin promotes the reaction [rosiglitazone results in decreased expression of CFLAR mRNA]PMID:16242776 PMID:19467017 PMID:19731824
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