GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ppard | affects response to substance | EXP | | 6480464 | CTD | PPARD protein affects the susceptibility to Carbon Tetrachloride | PMID:18622026 | Ppard | multiple interactions | EXP | | 6480464 | CTD | PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of BAX mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of BCL2A1A mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of BCL2A1B mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of BCL2A1C mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of BCL2L1 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of BDKRB1 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CCL2 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CCND1 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CCR5 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CD14 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CD74 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CSF3 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CXCR5 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of CYP2B10 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of ELF3 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of F3 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of GADD45B mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of HMOX1 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of ICAM1 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of IL1RN mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of IRF2BP2 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP12 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of MMP9 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of NFKB1 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of RELA protein]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of S100A6 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TAP1 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TGM2 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNC mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNFRSF12A mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNFRSF12A protein]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of TNIP1 mRNA]; PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of VIM mRNA] | PMID:18038451 PMID:18622026 | Ppard | decreases activity | ISO | Ppard (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in decreased activity of PPARD protein | PMID:25858767 | Ppard | decreases expression | ISO | Ppard (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in decreased expression of PPARD mRNA; Carbon Tetrachloride results in decreased expression of PPARD protein | PMID:25478064 | Ppard | increases expression | ISO | Ppard (Rattus norvegicus) | 6480464 | CTD | Carbon Tetrachloride results in increased expression of PPARB mRNA | PMID:31150632 | Ppard | multiple interactions | ISO | Ppard (Rattus norvegicus) | 6480464 | CTD | Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD mRNA]; Rutin inhibits the reaction [Carbon Tetrachloride results in decreased expression of PPARD protein]; schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of PPARB mRNA] | PMID:25478064 PMID:31150632 | | ||||||||||||||||||||||
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