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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731943
Species: Homo sapiens
RGD Object: Gene
Symbol: SLC12A1
Name: solute carrier family 12 member 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SLC12A1affects expressionISOSlc12a1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of SLC12A1 mRNAPMID:18606429
SLC12A1decreases expressionISOSlc12a1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of SLC12A1 mRNAPMID:19782052 PMID:22430074
SLC12A1multiple interactionsISOSlc12a1 (Mus musculus)6480464CTDIndomethacin inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC12A1 mRNA]; Indomethacin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SLC12A1 mRNA]; PTGES protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC12A1 mRNA]PMID:18617548 PMID:19782052 PMID:22430074
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