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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731911
Species: Mus musculus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:17230
Term: homocysteine
Definition: A sulfur-containing amino acid consisting of a glycine core with a 2-mercaptoethyl side-chain.
Chemical ID: MESH:D006710
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9multiple interactionsEXP 6480464CTDHomocysteine results in increased activity of and results in increased expression of MMP9 proteinPMID:22326992
Mmp9decreases expressionISOMmp9 (Rattus norvegicus)6480464CTDHomocysteine analog results in decreased expression of MMP9 proteinPMID:20406136
Mmp9increases activityISOMMP9 (Homo sapiens)6480464CTDHomocysteine results in increased activity of MMP9 proteinPMID:16251475
Mmp9increases expressionISOMMP9 (Homo sapiens)6480464CTDHomocysteine results in increased expression of MMP9 proteinPMID:16251475
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Acetylcysteine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased activity of MMP9 protein]; Staurosporine inhibits the reaction [Homocysteine results in increased expression of MMP9 protein]PMID:16251475
Mmp9multiple interactionsISOMmp9 (Rattus norvegicus)6480464CTDDizocilpine Maleate inhibits the reaction [Homocysteine analog results in decreased expression of MMP9 protein]PMID:20406136
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