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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731911
Species: Mus musculus
RGD Object: Gene
Symbol: Mmp9
Name: matrix metallopeptidase 9
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mmp9increases expressionISOMMP9 (Homo sapiens)6480464CTDDinoprostone results in increased expression of MMP9 mRNA; Dinoprostone results in increased expression of MMP9 proteinPMID:16330497 PMID:19880272
Mmp9increases secretionISOMMP9 (Homo sapiens)6480464CTDDinoprostone results in increased secretion of MMP9 proteinPMID:19880272
Mmp9multiple interactionsISOMMP9 (Homo sapiens)6480464CTD15-deoxyprostaglandin J2 inhibits the reaction [Dinoprostone results in increased expression of MMP9 mRNA]; 15-deoxyprostaglandin J2 inhibits the reaction [Dinoprostone results in increased secretion of MMP9 protein]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 mRNA]; Dinoprostone inhibits the reaction [isoliquiritigenin results in decreased expression of MMP9 protein]; Fenofibrate inhibits the reaction [Dinoprostone results in increased expression of MMP9 mRNA]; Fenofibrate inhibits the reaction [Dinoprostone results in increased secretion of MMP9 protein]PMID:19880272 PMID:25094029
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