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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731890
Species: Mus musculus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin dependent kinase 1
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1affects expressionISOCDK1 (Homo sapiens)6480464CTDGenistein affects the expression of CDK1 mRNAPMID:18847459
Cdk1decreases phosphorylationISOCDK1 (Homo sapiens)6480464CTDGenistein results in decreased phosphorylation of CDK1 proteinPMID:10601582
Cdk1increases expressionISOCDK1 (Homo sapiens)6480464CTDGenistein results in increased expression of CDK1 mRNAPMID:16474171
Cdk1increases phosphorylationISOCDK1 (Homo sapiens)6480464CTDGenistein results in increased phosphorylation of CDK1 proteinPMID:19038232
Cdk1multiple interactionsISOCDK1 (Homo sapiens)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]; Caffeine inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]; Genistein results in increased phosphorylation of and results in decreased activity of CDK1 protein; U 0126 inhibits the reaction [Genistein results in increased phosphorylation of CDK1 protein]PMID:11322924 PMID:19038232
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