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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731889
Species: Homo sapiens
RGD Object: Gene
Symbol: CDK1
Name: cyclin dependent kinase 1
Acc ID: CHEBI:8069
Term: phenobarbital
Definition: A member of the class of barbiturates, the structure of which is that of barbituric acid substituted at C-5 by ethyl and phenyl groups.
Chemical ID: MESH:D010634
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDK1increases expressionISOCdk1 (Rattus norvegicus)6480464CTDPhenobarbital results in increased expression of CDK1 mRNAPMID:19162173
CDK1increases expressionISOCdk1 (Mus musculus)6480464CTDPhenobarbital results in increased expression of CDK1 mRNAPMID:19482888 PMID:23091169 PMID:24690595 PMID:33549593
CDK1multiple interactionsISOCdk1 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CDK1 mRNA; [Methionine co-treated with Choline co-treated with Folic Acid co-treated with Betaine co-treated with Vitamin B 12 co-treated with Zinc co-treated with Phenobarbital] results in increased expression of CDK1 mRNA; NR1I3 protein affects the reaction [Phenobarbital results in increased expression of CDK1 mRNA]PMID:19482888 PMID:24535843 PMID:33549593
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