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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731889
Species: Homo sapiens
RGD Object: Gene
Symbol: CDK1
Name: cyclin dependent kinase 1
Acc ID: CHEBI:52289
Term: wortmannin
Definition: A delta-lactone that has formula C23H24O8.
Chemical ID: MESH:C009687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDK1multiple interactionsEXP 6480464CTD[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; wortmannin promotes the reaction [baicalein results in decreased phosphorylation of CDK1 protein]PMID:18025287 PMID:26385184
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