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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731889
Species: Homo sapiens
RGD Object: Gene
Symbol: CDK1
Name: cyclin dependent kinase 1
Acc ID: CHEBI:49900
Term: arsenous acid
Definition: An arsenic oxoacid consisting of three hydroxy groups attached to a central arsenic atom.
Chemical ID: MESH:C032793
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CDK1affects expressionEXP 6480464CTDArsenic Trioxide affects the expression of CDK1 mRNAPMID:18088464
CDK1decreases activityEXP 6480464CTDArsenic Trioxide results in decreased activity of CDK1 proteinPMID:10850458
CDK1decreases expressionEXP 6480464CTDArsenic Trioxide results in decreased expression of CDK1 protein modified formPMID:19825857
CDK1increases expressionEXP 6480464CTDArsenic Trioxide results in increased expression of CDK1 mRNAPMID:20862710
CDK1multiple interactionsEXP 6480464CTD[Arsenic Trioxide co-treated with Paclitaxel] results in increased activity of CDK1 protein; [Arsenic Trioxide co-treated with Paclitaxel] results in increased expression of CDK1 protein modified form; Arsenic Trioxide promotes the reaction [CDK1 protein binds to CDKN1A protein]; Arsenic Trioxide results in decreased expression of and results in increased phosphorylation of CDK1 protein; PTEN protein promotes the reaction [Arsenic Trioxide results in increased phosphorylation of CDK1 protein]PMID:10850458 PMID:19781537 PMID:22730174
CDK1multiple interactionsISOCdk1 (Rattus norvegicus)6480464CTDArsenic Trioxide results in increased expression of and results in increased phosphorylation of CDK1 proteinPMID:23337567
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