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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731867
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2a5
Name: cytochrome P450, family 2, subfamily a, polypeptide 5
Acc ID: CHEBI:68449
Term: 1,7-dimethyluric acid
Definition: An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trione substituted by methyl groups at N-1 and N-7. It is a metabolite of caffeine and is often found in human urine samples.
Chemical ID: MESH:C053084
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2a5increases chemical synthesisISOCYP2A6 (Homo sapiens)6480464CTDCYP2A6 protein results in increased chemical synthesis of 1,7-dimethyluric acidPMID:12505289
Cyp2a5multiple interactionsISOCYP2A6 (Homo sapiens)6480464CTD[CYP2A6 protein results in increased metabolism of 1,7-dimethylxanthine] which results in increased chemical synthesis of 1,7-dimethyluric acidPMID:19215233
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