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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731867
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2a5
Name: cytochrome P450, family 2, subfamily a, polypeptide 5
Acc ID: CHEBI:32188
Term: Tegafur
Definition: A pyrimidine that has formula C8H9FN2O3.
Chemical ID: MESH:D005641
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2a5affects metabolic processingISOCYP2A6 (Homo sapiens)6480464CTDCYP2A6 gene polymorphism affects the metabolism of Tegafur; CYP2A6 protein mutant form affects the metabolism of TegafurPMID:15980104 PMID:18212800
Cyp2a5decreases activityISOCYP2A6 (Homo sapiens)6480464CTDCYP2A6 protein mutant form results in decreased activity of TegafurPMID:15980104
Cyp2a5increases metabolic processingISOCYP2A6 (Homo sapiens)6480464CTDCYP2A6 protein results in increased metabolism of TegafurPMID:11376561 PMID:12172220 PMID:18212800
Cyp2a5increases response to substanceISOCYP2A6 (Homo sapiens)6480464CTDCYP2A6 protein results in increased susceptibility to TegafurPMID:11376561
Cyp2a5multiple interactionsISOCYP2A6 (Homo sapiens)6480464CTDCYP2A6 protein affects the metabolism of and results in increased activity of TegafurPMID:15980104
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