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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731867
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp2a5
Name: cytochrome P450, family 2, subfamily a, polypeptide 5
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2a5increases expressionISOCYP2A6 (Homo sapiens)6480464CTDEstradiol results in increased expression of CYP2A6 mRNAPMID:17646279 PMID:22837389
Cyp2a5multiple interactionsISOCYP2A6 (Homo sapiens)6480464CTDafimoxifene inhibits the reaction [Estradiol results in increased expression of CYP2A6 mRNA]; ESR1 protein promotes the reaction [Estradiol results in increased expression of CYP2A6 mRNA]; Estradiol promotes the reaction [ESR1 protein binds to CYP2A6 promoter]; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CYP2A6 mRNA]PMID:17646279
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