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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731838
Species: Mus musculus
RGD Object: Gene
Symbol: Cga
Name: glycoprotein hormones, alpha subunit
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cgaincreases expressionISOCGA (Homo sapiens)6480464CTDnickel sulfate results in increased expression of CGA mRNAPMID:18651567
Cgamultiple interactionsISOCga (Rattus norvegicus)6480464CTD[CGA protein co-treated with nickel sulfate] results in decreased expression of CYP11A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP11A1 protein; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of CYP17A1 protein; [CGA protein co-treated with nickel sulfate] results in decreased expression of HSD17B3 mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of STAR mRNA; [CGA protein co-treated with nickel sulfate] results in decreased expression of STAR proteinPMID:29567110
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