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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731838
Species: Mus musculus
RGD Object: Gene
Symbol: Cga
Name: glycoprotein hormones, alpha subunit
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cgadecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CGA mRNAPMID:24793433
Cgamultiple interactionsEXP 6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CGA mRNAPMID:17942748
Cgadecreases expressionISOCga (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of CGA mRNAPMID:22493514
Cgaincreases expressionISOCga (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of CGA mRNAPMID:21187122
Cgamultiple interactionsISOCga (Rattus norvegicus)6480464CTDCGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of ESR1 protein]; CGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of NR3C1 protein]; CGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLAT protein]; CGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PLAU protein]; CGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 protein]; CGA protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINE1 protein]; CGA protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of NR3C1 protein]; Estradiol inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CGA mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [PTGS2 protein results in increased expression of CGA mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [PTGS2 protein results in increased expression of CGA protein]PMID:12128104 PMID:21187122
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