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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731838
Species: Mus musculus
RGD Object: Gene
Symbol: Cga
Name: glycoprotein hormones, alpha subunit
Acc ID: CHEBI:15930
Term: atrazine
Definition: A diamino-1,3,5-triazine that is 1,3,5-triazine-2,4-diamine substituted by a chloro group at position 6 while one of hydrogens of each amino group is replaced respectively by an ethyl and a propan-2-yl group.
Chemical ID: MESH:D001280
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cgaaffects methylationISOCga (Rattus norvegicus)6480464CTDAtrazine affects the methylation of CGA genePMID:28931070
Cgaincreases expressionISOCGA (Homo sapiens)6480464CTDAtrazine results in increased expression of CGA mRNAPMID:18461179
Cgamultiple interactionsISOCGA (Homo sapiens)6480464CTDAtrazine inhibits the reaction [[FSHB protein co-treated with CGA protein] results in increased expression of AREG mRNA]; Atrazine inhibits the reaction [[FSHB protein co-treated with CGA protein] results in increased expression of EREG mRNA]PMID:28859905
Cgamultiple interactionsISOCga (Rattus norvegicus)6480464CTD[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA]; [Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of EREG mRNA]; [Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]; [CGA protein affects the susceptibility to Atrazine] which results in increased expression of SCARB1 mRNA; [CGA protein affects the susceptibility to Atrazine] which results in increased expression of STAR mRNA; [CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA; [Egtazic Acid co-treated with 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester] inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA]; bisindolylmaleimide I inhibits the reaction [[CGA protein co-treated with Atrazine] results in increased expression of STAR mRNA]; U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of AREG mRNA]]; U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of EREG mRNA]]; U 0126 inhibits the reaction [[Atrazine inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]] inhibits the reaction [CGA protein results in increased expression of PGR mRNA]]PMID:23583632 PMID:27554787
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